hi Joedodge:
It looks like you lost your cycle. Since you have fish living there, I would recommend daily partial water changes (close to but not over 50%) and add tap water treated with a product such as Seachem's Prime, that besides removing chlorine/chloramines, will keep ammonia and nitrites locked -but capable to feed bacteria- within tolerable limits for your fish, for some 24 hours.
Melafix is not really a medication, but a tonic that might help healing the skin, scales, maybe even soft tissues. If your fish have some bacterial infection that is causing this (e.g. columnaris) Melafix might aid a bit but will not suffice. Having said this, if your fish lesions look bad, consider using broad-spectrum antibiotics. You must remove activated charcoal media if it is new (say a week old).
Most bacterial infections in fish -though not all- are from gramm-negative bacteria; using Maracyn (I recommend the saltwater formulae, since it has added vitamins) should help; however, since your cycle is disrupted, you may have a catch 22 situation here: Maracyn (Erythromycine) works by gradually reaching optimal levels in the fish plasma as a function of a gradual build-up in its concentration in water. Removing water daily, may require treating your fish for more than the usual 5-7 days, keep that in mind.
Your filtration, in my opinion, is under what I consider desirable minimum (10 times tank's volume per hour) -although this "rule" is usually for HOBs not for canister or wet/dry systems. A canister filter excells HOBs in surface for biological filtration, however, having only one filter -of course, your seeded substrate is another bio-filter, but you likely cleaned it too: I divide the tank for vacuuming purposes, one half each week -expose you to situations like this one: mini-cycles. You should carefully rinse/replace its media, however, since dirty canisters can become quite efficient Nitrates factories.
If you have a seeded HOB in another tank, consider using it in your 75gal (or at list using some sponge media from it) and for the time being, raise your temp a bit, to 82F, increase dissolved oxygen (water agitation, airstones). Once this is over, consider using activated charcoal to remove loose chemicals from the water (meds).
Hope your fish heal soon. Pics, as ricky said, could be very helpful in order to do "differential diagnosis" for the experts down here. I'm just a newbie. Good luck.
Pepe
Santo Domingo