I'm not really sure whether these products like stress zymne actually do anything. People are taken in by them and actually think that they create a biological filter, this is totally untrue. They help maintain your aquarium while you're biological filter is being created.
Okay, when you ammonia starts rising above .25, that is the time to start doing water changes, if it doesn't rise above this then a water change is not necessary, you've got to remember that you need a food source for your bacteria to grow, this is ammonia, if you haven't got any ammonia present, you can't grow the bacteria colony