yes, I totally agree hole in the head disease is a real bitch.okay, melafix isn't the correct medication to use, it won't actually have any effect. Could you possibly post some photograph for us to have a look? this disease doesn't always get brought on by poor water conditions, it can be brought on by stress which can be caused by other factors. Such as large rapids changes in water temperature. this is why it's important to try and match the temperature in the tank when you actually do water changes. As long as your water is in good condition then I shouldn't start stressing about why this has happened, trying to clear it up and then you can look at your situation and try and understand why this happens, you may never understand why it happened. I have had fish that have developed this disease and I always keep the water in really good condition